Superficial bcc dermoscopy. [1] It may also present as a raised area with ulceration.

Superficial bcc dermoscopy The prognosis for patients with BCC is excellent, but if the disease is allowed to progress, it can cause significant morbidity. 22, 23 Dermoscopic criteria for BCC are the absence of brown reticular lines (pigment network), branching and linear vessels (arborising and superficial telangiectasias), multiple erosions, ulceration, bluish-gray What are perpendicular white lines? In dermoscopy, perpendicular white lines are short discrete white lines oriented parallel and orthogonal (perpendicular) to each other and seen only under polarised light [1]. A biopsy was performed and confirmed the diagnosis of superficial basal cell carcinoma. Elliptical excision biopsy with a 3-mm free margin was done under local anesthesia after obtaining Superficial variant presents with scaly macules, patches or plaques with an erythematous surface Pigmented variant resembles a nodular or superficial BCC but has a pigmented surface and can be clinically mistaken for a melanoma; Neglected tumors may result in massive skin, soft tissue and bone destruction with severe disfiguration Their differential diagnosis is wide and includes SCC in situ (Bowen’s disease), superficial BCC, and seborrheic keratosis . Shiny white View pictures of basal cell carcinoma (BCC) in the gallery below. It is the most common form of skin cancer. a Clinical photograph of a 42-year-old male patient with a pink-colored, slowly growing nodule on the left forearm for 1 year. red areas and multiple small ulcer- ations or erosions can provide reassurance that the lesion under investigation is a superficial BCC. Superficial BCC is characterized by erythematous patches ranging from a few TOOL & DERMOSCOPY. gov) from Basal cell carcinoma (BCC) is the most common form of cutaneous neoplasia in humans, and dermoscopy may provide valuable information for histopathological classification of BCC, which allows for the choice of non-invasive topical or surgical therapy. Background: The dermoscopic features of superficial basal cell carcinoma (sBCC) and Bowen's disease (BD) have been extensively investigated, and dermoscopy was shown to significantly improve their recognition. Introduction. Superficial BCC was diagnosed based on clinical symptoms, a dermoscopy, and histopathology. The sensitivity and specificity of dermoscopy were Diagnostic accuracy is enhanced by good lighting, the skin stretch test 21 and dermoscopy. They are slightly dry or scaly and are often eroded and crusted. Images, demographic and dermoscopic data were collected by a melanographer. These nests contribute to the distinctiveness of BCC dermoscopy . 2,3 Dermoscopy is a helpful In the non-superficial BCC, dermatoscopy is used in presurgical ex cision margins markin g since it can dete ct a sub-clini cal tumor expansion by r evealing disease-related f eatures in Basal cell carcinoma (BCC) is the most common, accounting for 80–90% of skin cancers. Maple leaf-like areas. Dermoscopy has an invaluable role in the diagnosis of BCC, with well-established criteria for superficial and nodular subtypes [6,7,8,9,10]. Superficial BCC is the most common type of BCC found in younger adults. In the non-superficial BCC, dermatoscopy is used in presurgical excision margins marking since it can detect a sub-clinical tumor expansion by revealing disease-related features in peripheral areas of clinically healthy skin. Pigmented lesions (PLs) often have similar characteristics that overlap and can mislead a clinician’s diagnosis. Braun. The main dermoscopic features of superficial BCC are shiny white to red areas, superficial fine telangiectasias (SFT) and multiple small erosions. This comprehensive review aims to provide a succinct overview of the current state of knowledge regarding the etiological factors, pathogenesis, clinical presentation, and management of BCC. 5% of cases. The main dermoscopic features seen in superficial spreading melanoma of the trunk and the extremities are: As a rule, dermoscopy of superficial spreading melanoma of the trunk and the extremities reveals asymmetry of shape, more than 2 colors (light brown, dark brown, black, blue, gray, red, white) and asymmetry of structures. PubMed PMID: 25786770. Basal cell carcinoma (BCC) is a slow growing, locally aggressive tumor that arises from the basal layer of the epidermis. Structureless white / red areas Focal areas of erosions / ulceration; Vascular appearance - peripheral, parallel, finely-looped vessels (and sometimes short arborising Basal-cell carcinoma (BCC), also known as basal-cell cancer, basalioma [7] or rodent ulcer, [8] is the most common type of skin cancer. The most important difference between infiltrative and nodular BCC upon dermoscopy is the higher occurrence of superficial fine telangiectasia in the former. Background: There is limited data on dermoscopic features of basal cell carcinomas (BCCs). We have In cases of BCC diagnosis, it may help in the differentiation of BCC from melanoma, invasive and in situ CSCC, and benign tumors. Dermoscopy. To date, dermoscopy is considered a key tool for the diagnosis of BCC; nevertheless, line-field confocal optical coherence tomography (LC-OCT), a new non-invasive optical technique, has become increasingly important in clinical practice, allowing for in vivo imaging at cellular A shave biopsy specimen was obtained, and the subsequent histopathologic examination confirmed the diagnosis of superficial BCC (). It may be an option for treating superficial skin lesions. Superficial BCC. 2% and 95%, respectively. [1] It may also present as a raised area with ulceration. 22, 23 Dermoscopic criteria for BCC are the absence of brown reticular lines (pigment network), branching and linear vessels (arborising and superficial telangiectasias), multiple erosions, ulceration, bluish-gray Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. The provisional clinical diagnosis was basal cell carcinoma. 2, 3 Dermoscopy is a helpful The sensitivity and specificity of BCC diagnosis were significantly improved after adding dermoscopy to the naked‐eye examination. This is page „Correlation of dermoscopic structures of basal cell carcinoma“. 9% to 85% (P = . 8% was found between the two markings . Dermoscopy structures can be divided into three categories: vascular, pigment-related, and nonvascular Diagnostic accuracy is enhanced by good lighting, the skin stretch test 21 and dermoscopy. Comparative Analysis. LESSONS ON DERMOSCOPY Dermoscopic Monitoring of Tazarotene Treatment of Superficial Basal Cell Carcinoma K ETTY P ERIS , MD, n A NGELA F ERRARI , MD, n M ARIA C ONCETTA FARGNOLI , MD, n D OMENICO P ICCOLO , MD, n AND S ERGIO C HIMENTI , MD w Department of Dermatology, University of L’Aquila, L’Aquila, Italy; wDepartment of Dermoscopy is a noninvasive technique that has been demonstrated to improve diagnostic accuracy in basal cell carcinoma (BCC). In addition to a diagnosis of BCC, dermatoscopy also allows for distinction between different histologies, as many dermatoscopic features correlate directly with specific histologies. PDT is approved in many European countries for the treatment of BCC, mainly primary superficial BCCs at low-risk sites. The most important facts to know about BCCs are that: Superficial BCC; Most commonly affect the trunk (chest, abdomen, back) or lower legs, but can affect any part of the and for differentiating BCC subtypes. The first dermoscopic model for the diagnosis of BCC, based mainly on Haspeslagh M, Noë M, De Wispelaere I et al. PBCC vs. Ulcerations are frequent in BCC and are significantly specific in the absence of other signs for a melanoma. (d and for differentiating BCC subtypes. 3%) Blue globules (n = 1, 5. dermoscopedia. 1 Clinicopathologic appearances of BCC are various and include nodular, superficial, morpheic, and pigmented variants. Because of the high diagnostic accuracy achieved Dermatoscopy improves the clinical diagnosis of BCC, enabling its detection even at an early stage, when the tumor is still clinically inconspicuous (Figure 5). The classic dermoscopic patterns, first described by Menzies and colleagues [], includes the recognition of at least one of the following dermoscopic structures: ulceration (with no trauma history), multiple Finally, most studies are based on non-homogeneous BCC dermoscopic image series, acquired by different instrumentation and magnification (9, 10). Dermoscopy improves the diagnostic accuracy and enables the distinction of certain subtypes of BCC. Recently, the dermoscopy of Fibroepithelioma of Pinkus has also been described with the presence of fine arborizing Currently, there are a few studies that evaluate diagnostic values (sensitivity and specificity) of dermoscopic features of BCC in the skin of color. 69, 81, 82, 85-87 In these studies, Dermoscopic characteristics for each BCC subtype have been described. Superficial BCC is the second most common clinical subtype, accounting for up to 15% of cases []. [78, 79] Several studies have shown imiquimod to be curative in all patients with superficial BCC if used twice daily and in 73-82% of patients when used once a day for 6-12 weeks. There are multiple histopathologic subtypes of BCC. This is a common subtype of BCC. There is a direct link between ultraviolet exposure and the development of BCC, as UV exposure damages DNA and induces mutations in tumor Differentiation of superficial BCC from other subtypes is the most important issue, as it may determine further management decisions. Superficial BCC is the second most common type of BCC and usually presents as a plaque or patch of well-defined, scaly, pink skin. In our study, shiny white-red structureless background and shiny Superficial variant presents with scaly macules, patches or plaques with an erythematous surface Pigmented variant resembles a nodular or superficial BCC but has a pigmented surface and can be clinically mistaken for a melanoma; Neglected tumors may result in massive skin, soft tissue and bone destruction with severe disfiguration On dermoscopy, a pattern of arborizing vessels is seen. Summary. Dermoscopy structures can be divided into three categories: vascular, pigment‐related, and nonvascular Dermoscopy is another aid to diagnosis which we feel that at least one member of every practice should be competent to use. Basal cell carcinomas (BCCs) are the most common nonmelanoma skin cancers. 2% (P = . More striking, however, was the presence of numerous well-defined yellow-white globules of unknown nature, starting within the telangiectatic area but spreading well beyond the known BCC criteria (Figure 1B). The dermoscopy image of the bigger lesion (b) in Figure 2 shows arborising vessels and pink-white areas in the background. The Our study identifies the presence of shiny white to red areas, SFTs and "erosions" as main dermoscopic criteria of superficial BCC. Other Skin Cancers. Compared to other skin cancers, PBCC has distinct dermoscopic features: Feature PBCC The field of pigmented BCC dermoscopy has seen remarkable advancements, significantly improving our ability to diagnose and manage this Evaluate the preoperative accuracy of dermoscopy and RCM in determining BCC excision margins by drawing dermoscopic borders, creating superficial incisions as markers, utilizing confocal imaging to assess BCC features, and subsequently conducting histopathological examinations on surgically excised specimens. J Eur Acad Dermatol Venereol. the presence of maple leaf-like areas (peripheral radial lines) with superficial fine telangiectasias is typical for superficial BCC. The dermatoscope image of the smaller lesion on the left (a) in Figure 3 is also diagnostic for BCC. Superficial BCC is an erythematous, well-circumscribed macule with minimal scale. Cystic BCC is soft with jelly-like contents. For example, the presence of glomerular vessels is strongly The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of basal cell carcinoma (BCC). 33. The example images have been approved by a panel of experts as Dermatoscopy of the first case revals superficial fine telangiectasia and few blue-gray dots, suggestive of the diagnosis of superficial BCC (a). 2019. Objective: To systematically review the prevalence of dermoscopic structures in BCC and its subtypes. Skip to search form Skip to main content Skip to account menu. 123. Imiquimod cream is an immune response modifier used for treatment of low risk superficial BCC. b Dermoscopy revealed arborizing telangiectasia. Although surgery is considered the gold-standard therapy, new current pharmacological opti Dermoscopy. The diagnosis of BCC is generally straightforward integrating clinical and dermoscopic examination, although in a minority of cases BCC may simulate other benign and malignant tumors (2–6). In addition, recent evidence highlighted that dermoscopy is also useful in the management of BCC, since it provides information on the tumor 56-year-old patient presented with a poorly delimited (Fig. R. 006). 6 million cases diagnosed each year. In this regard, there is growing evidence that dermoscopy may benefit the recognition of BCC even for skin of color (SoC). Dermoscopy is an indispensable tool to differentiate superficial BCC from other subtypes and between pigmented and not pigmented ones. Superficial BCC: multiple erosions and scales on a pink homogenous area; B) Pigmented superficial BCC: radial lines connected to a common base (leaf-like areas), radial lines converging to a central dot or clod (spoke-wheel The dermoscopic appearance of BCC includes any of - gelatinous background, well-focused arborising vessels, central ulceration, blue-grey globules and ovoid structures Compared to Bowen's, superficial BCC tend to have small surface erosions as Dermoscopy revealed a few arborizing vessels and a pinkish area, suggestive of nodular BCC. Derm-dotting is the marking with nail polish of suspicious areas seen in dermoscopy, Superficial BCC is the second most common type of BCC and usually presents as a plaque or patch of well-defined, scaly, pink skin. [Updated 2022 Sep 19]. was the most common clinical presentation followed by pearly form and cicatricial BCC. His-tological clearance rates in Phase II studies have been higher for subjects with sBCC than those with nBCC. This medication promotes apoptosis in skin cancer cells by interfering with the anti Basal cell carcinoma (BCC) arising within scar tissue is a rare but clinically significant phenomenon. It has been shown that dermoscopy improves the diagnostic accuracy of BCC, with a sensitivity of 98. Nonpigmented actinic keratosis on the face is characterised by a 'strawberry pattern' on dermoscopy. 1), mixed type (superficial, nodular and infiltrative) basal cell carcinoma (BCC). Another intriguing, pigmented feature, the maple leaf-like areas, showcases bulbous extensions connected at a base, typically exhibiting shades of brown or gray The findings of our study resemble those of Micantonio et al. Content is available under Creative Commons Attribution-NonCommercial-ShareAlike 4. 1,2 Epidemiologic data indicate that the global incidence is increasing worldwide particularly in younger age Invasive squamous cell carcinoma can be difficult to diagnose by dermoscopy alone. In: StatPearls [Internet]. Differentiation between actinic keratoses and disseminated superficial Short and superficial telangiectasias (n = 5, 26. •More common in superficial BCC than nodular BCC Vascular dermoscopic features 54 Reiter O; et al. It is also known as rodent ulcer and basalioma. A dermatoscope usually consists of a light source, achromatic lens, contact plate, and power supply. Cryosurgery might be considered for treating small and thin basal cell carcinomas when surgery isn't an option. They are also known as polarising white lines, short white lines, shiny white lines, shiny white streaks, chrysalis, chrysalids, and crystalline structures. Dermoscopy can predict the diagnosis of Arborizing vessels correspond to dilated vessels in the dermis and are the dermoscopic hallmark of nodular BCC. Recent Findings Several factors influence the selection of treatment Superficial BCC occur more commonly in younger patients, and present most frequently on the trunk and shins as a slowly expanding pink-red patch. The method increases the accuracy of basal cell carcinoma (BCC) detection. Dermoscopy . These fine arborizing vessels, which Point-like pigmented deposition in the central portion of spoke wheel areas of the superficial type of BCC in dermoscopy bore histopathologically an amorphous pigmented material with surrounding a slit formation. jaad. The pooled sensitivity and specificity of dermatoscopy for the diagnosis of BCC Dermoscopedia is the online resource for dermoscopy and is provided by the international dermoscopy society. After the acquisition of nineteen dermoscopic images with an overlap of 30% (Fig. 22, 23 Specialist noninvasive skin imaging tools, including reflectance confocal microscopy and optical coherence tomography, Topical PDT is a widely studied treatment option for low-risk, superficial BCC. Semantic Scholar's Logo. Treatment options for this tumor include electrodesiccation and 1. Tschandl et al : Forschner T, Röwert-Huber J, et al. clinicaltrials. 2% and 95. [11,17,18,19] In this study, we decided to investigate the diagnostic value of dermoscopy in distinguishing superficial BCC from other types of BCC in patients with dark skin complexion referred to Basal cell carcinoma (BCC) is a slowly growing malignant epithelial skin tumor predominantly affecting middle-aged and fair-skinned individuals. A complex interplay of environmental, phenotypic and genetic variables leads to the development of BCC. Features that suggest the diagnosis of superficial BCC are the absence of significant white, adherent scale and a history of the lesion remaining unchanged for several months or years. 1 In addition, it has several histopathologic subtypes, with the most common being nodular Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. These structures were equally visible with Introduction. 008 Dermoscopy features of BCC in H- and non-H zone were described and a comparative study of the dermoscopic pattern of BCC between the two locations was performed. 2% to 98. Dermoscopy of a BCC showing arborizing vessels (*), brown-gray globules and maple leaf like areas at the periphery. , and since then dermoscopy has generated an abundance of literature Imiquimod 5% cream (Aldara) is approved by the US Food and Drug Administration for the treatment of nonfacial superficial BCC. emphasize that the white shiny blotches/strands structure is a predictor of superficial BCC in anatomic sites other than the lower extremities . Some studies [50–52] also tried to differentiate between superficial basal cell carcinomas and other subtypes by dermatoscopy, which may have important consequences for treatment. 5-FU is only considered if superficial BCC in a noncritical location. It is also known as dermatoscopy, epiluminescence microscopy, incident light microscopy, and skin-surface microscopy [1,2]. A dermatoscope allows better visualisation Background: Multiple studies have reported on dermoscopic structures in basal cell carcinoma (BCC) and its subtypes, with varying results. Moreover, during the process of forming a wheel structure, nuclei Specific criteria are described for the accurate diagnosis of BCC by dermoscopy. 6% to 30. Dermoscopy has been shown to be effective for discriminating BCC from other skin tumours, with a sensitivity of 95 to 97% In this case, the dermatoscopic images were very highly suggestive of BCC. The diagnosis Pigmented and nonpigmented variants of basal cell carcinoma present different dermoscopic features. Superficial BCC is characterized by erythematous patches ranging from a few What are the dermoscopic features of actinic keratosis? Nonpigmented actinic keratosis on the face. Dermatoscopy has also been assessed as a valuable method to differentiate BCC from other skin tumors and inflammatory skin diseases [1,9,13]. In the single-center study by Chen et al. [1] Basal-cell cancer grows slowly and can damage the tissue around it, but it is Introduction. IBOOLO explores dermoscopy's role in detecting superficial basal cell carcinoma (BCC). 9 Dermoscopy facilitates the discrimination of sBCC from tumoral and inflammatory diseases commonly included in its differential diagnosis. [11,17,18,19] In this study, we decided to investigate the diagnostic value of dermoscopy in distinguishing superficial BCC from other types of BCC in patients with dark skin complexion referred to Superficial BCC is the second most common BCC subtype with a predilection on the trunk including the waist and can be treated with cryoimmunotherapy, a combination of cryotherapy and imiquimod cream. Smaller studies have shown similar BCC’s dermoscopy includes features that vary with age, sex, race, defined for superficial BCC are correctly determined, the rate of correct diagnosis increases to 99% [10]. (B) Dermoscopic Dermoscopic variables were selected on the basis of previously published data on dermoscopy of BCC and included: (1) arborizing vessels, (2) blue-gray ovoid nests, (3) ulceration, (4) multiple blue-gray dots/globules, (5) maple leaf–like areas, (6) spoke-wheel areas, (7) superficial fine telangiectasias, (8) multiple small erosions, (9 Dermoscopy is a noninvasive technique that has been demonstrated to improve diagnostic accuracy in basal cell carcinoma (BCC). As vascular formation and angiogenesis are indicators of tumor development Pigmented BCC is a variant of nodular or superficial BCC, which contains melanin pigment derived from an increased number of dendritic melanocytes within the malignant tumor nests, being found within the Basal cell carcinoma (BCC) is the most common human cancer worldwide, and even though it rarely metastasizes, it may cause significant morbidity if left untreated. [2] It often appears as a painless raised area of skin, which may be shiny with small blood vessels running over it. Dermoscopy is a non-invasive technique used to examine skin lesions with a dermatoscope. Dermatoscopy of Keywords: basal cell carcinoma, BCC, dermoscopy, USG, histology. It may have the appearance of psoriasis, eczema or tinea and is sometimes treated as one of these conditions before a correct Introduction: Dermoscopy aids in identifying histopathological subtypes and the presence of clinically undetectable pigmentation in basal cell carcinoma (BCC). This study constitutes a literature review pertaining to BCC, with a Dermoscopy registrar teaching, BCC, Amanda Oakley. The most common dermoscopic structures described in sBCC were short-fine telangiectasia (60%, 95% CI 51%−69%), multiple small erosions (43%, 95% CI Dermoscopy improves diagnostic accuracy for BCCs, helps differentiate BCCs from other neoplastic and inflammatory disorders, and allows for improved prebiopsy differentiation One of the most recent applications of dermoscopy in BCC is as an aid to predicting histologic subtype and essentially differentiating between superficial and nonsuperficial BCC. Our aim was to investigate the dermoscopy in BCC is as an aid to predicting histologic subtype and essentially differentiating between superficial and nonsuperficial BCC. This study investigated dermoscopic patterns of superficial Dermoscopy is a noninvasive technique that is known to increase the diagnostic accuracy of benign versus malignant The histologic characteristics of superficial BCC include buds and irregular proliferations of tumor cells attached to atrophic epidermis. 2), we merged them with Adobe Photoshop software (Adobe Systems Incorporated, San Jose, CA, USA, v19. Fortunately this is the least dangerous of the skin cancers but the risk is with local spread and destruction of tissues. This paper aims to review available data on the role of dermoscopy not only in the management of BCCs in everyday practice and mainly in selecting tumors that may be treated non-surgically. (1) Superficial BCCs have been shown to be independently associated with location on Background/Aim: Basal cell carcinoma (BCC) is a common skin cancer, especially in the elderly population. It can also, however, help raise suspicion of more Dermoscopy can help identify different subtypes of skin cancers, which can have important therapeutic implications. By the time in situ and invasive superficial spreading melanoma (SSM) is recognised as a changing or distinctive lesion by the patient or their doctor, it is often large (>6mm). 11. [4, 5] There are few differences in dermoscopic patterns of superficial, nodular and pigmented BCC (pBCC). It can be more difficult for the teledermoscopist, who is unable to palpate the lesion. Patients with BCC often develop multiple primary tumours over time. The objective of this review is to provide an up-to-date overview on clinical and 5 According to a recent systematic review, the most common dermoscopic structures in superficial BCC are short fine telangiectasias (60%), multiple erosions (43%), and shiny white structures (43% Clinically, BCC can present with a variety of morphologies, ranging from erythematous patches to ulcerated nodules. Besides nodular BCC, superficial BCC is one of the most common types typically occurring on the trunk as a scaly, pink to red-brown patch which can easily be ignored by the patient or doctors There is limited evidence to support the use of 5-FU for treatment for superficial BCC. 1111/jdv. Search 222,476,548 papers from all fields of science Dermoscopy, also known as epiluminescence microscopy, or skin surface microscopy, is a non-invasive, in-vivo technique, which has traditionally found use in the evaluation and differentiation of suspicious melanocytic lesions from dysplastic lesions and melanomas, as well as keratinocyte skin cancers such as basal cell carcinoma (BCC) and Basal cell carcinoma (BCC) is the most common human skin cancer, comprising more than half of all non-melanoma skin cancer diagnoses, that affect more than 3 million Americans annually. Statistics; Basal Cell Carcinoma (BCC) Squamous Cell Carcinoma (SCC) Basal Cell Carcinoma (BCC) Home Basal Cell Carcinoma (BCC) BCC is the commonest skin cancer and can occur at any age but are more common as you age. Specific dermoscopy criteria have been recognized in different subtypes of BCC. Differentiation of superficial BCC from other subtypes is the most important issue, as it may determine further management decisions. Learn key features, challenges & applications for early diagnosis of this common skin cancer. BCC is a common, locally invasive, keratinocyte cancer (also known as non-melanoma cancer). 3%) Hairpin vessels (n = 1, 5. , with 107 BCC patients, dermoscopy was also compared with visual margin marking of BCC, and a discrepancy of 16. Some reports differentiated between superficial BCC and other subtypes by dermoscopy (19, 24, 25). This slit formation fits the space filled with lubricating oil. especially for superficial BCC . M. The histopathologic findings that correspond to the spoke wheel–like structures seen under dermoscopy and the stellate-shaped bright tumor islands seen under RCM are neoplastic basaloid aggregates in the papillary dermis that emanate from Dermoscopy is a noninvasive technique that has been demonstrated to improve diagnostic accuracy in basal cell carcinoma (BCC). Advertisement. May 2023. In superficial BCC, maple leaf-like areas, spoke wheel areas, SFTs, multiple small erosions, and concentric structures were frequently observed (17–19, 23). Blue-gray ovoid nests are visualized in case of pigmentation. A nodulocystic BCC is a small and slow-growing translucent lesion with rolled edges and telangiectasia. Although BCCs rarely metastasize, these tumors commonly destroy underlying tissues and should therefore be treated promptly. Dermoscopy is widely used in dermatological practice. (2) Methods: We conducted a prospective study including 46 BCC cases, which were analyzed with dermatoscopy using the The pooled sensitivity and specificity of dermoscopy for the diagnosis of BCC were 91. A variety of different phenotypic presentations of BCC are possible. Dermoscopy registrar teaching, BCC, Amanda Oakley. Expand. For example, dermoscopic structures more frequently associated with non-superficial, mostly nodular BCC, are blue-ovoid nests, arborizing vessels, and ulceration, and warrant surgical excision. , who analyzed 504 cases of BCC and detected at least one vascular pattern in 91. ) searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and the ongoing trials registry of the United States National Institutes of Health (www. Superficial BCC presents as one or more often multiple, slowly growing thin erythematous plaques, with a slightly blue tinge. Superficial BCC The pooled sensitivity and specificity of dermatoscopy for the diagnosis of BCC were 91. Short fine telangiectasia. The pooled sensitivity and specificity of dermatoscopy for the diagnosis of BCC were 91. Herein, we report a case of superficial BCC in a 60-year-old woman which was triggered by short-wave diathermic (SWD) therapy on the waist one year previously. 25-26 Therefore, the present study also evaluated the difference in dermoscopic features between superficial BCC Purpose of Review The diagnostic value of dermoscopy for basal cell carcinomas (BCCs) is well established. 1 In addition, it has several histopathologic subtypes, with the most common being nodular The findings suggest that MAY globules may have utility as a new BCC dermoscopic criterion with a high specificity. 008 Superficial BCC is the second most common BCC subtype with a predilection on the trunk including the waist and can be treated with cryoimmunotherapy, a combination of cryotherapy and imiquimod cream. Similarly, dermoscopy may allow for the identification of incipient forms of BCC that cannot be detected Dermoscopic characteristics for each BCC subtype have been described. Basal cell carcinoma is usually a slow-growing tumor for which metastases are rare. Superficial basal cell carcinoma (BCC) presents as a scaly, pink to red-brown patch and is predominantly located on the trunk. Elliptical excision biopsy with a 3-mm free margin was done under local anesthesia after obtaining . Telangiectasia of iBCC have smaller Superficial BCC occur more commonly in younger patients, and present most frequently on the trunk and shins as a slowly expanding pink-red patch. BCC mostly arises on sun-damaged skin and rarely develops on the mucous membranes or palms and soles. Papageorgiou et al. We evaluated the presence of dermoscopic features in superficial (sBCCs), nodular (nBCCs), pigmented and Basal cell carcinoma (BCC) is the most common, accounting for 80–90% of skin cancers. Dermoscopy of actinic keratoses A 71-year-old man presented an erythematous lesion on his back. It Below are dermoscopic features commonly associated with the diagnosis "Basal cell carcinoma". Several Excision of nodular or superficial BCC with 3- to 4-mm margins in low-risk anatomic locations was associated with 2% to 4% recurrence rates after 3 to 5 years. Methods: Databases and reference lists were searched for relevant trials according to Preferred Reporting Items for Systematic Reviews and The diagnosis of basal cell carcinoma (BCC) in dark phototypes can be a challenging task due to the lack of relevant clues and its variable presentation. About 2000 deaths annually in the United States are attributed to basal and squamous cell skin cancers. 3. It can also, Superficial BCC usually presents on the trunk as a sharply demarcated, erythematous, scaling thin plaque with a pearly border (Fig. Bowen's disease (BD) or squamous cell carcinoma in situ is usually nonpigmented, but may also rarely be pigmented. Superficial basal cell carcinoma clinical and dermoscopic features. Basal cell carcinoma (BCC), previously known as basal cell epithelioma, is the most common cancer in Humans. No gray-blue ovoid nests or globules were seen. 1 Superficial Horizontal Branched Vessels [2, 7] Prominent vasculature that is enlarged, horizontal, branched, with a slow flow and sometimes white blood cells are seen hugging the lumen wall (traffic rolling phenomena). 6% and a specificity A superficial BCC usually presents as a well defined red patch, typically on the body or limbs (Figure 2). On Dermnet. 1 The estimated incidence of BCC in Spain is approximately 250 cases per 100 000 person-years. It is estimated that over 50,000 non-melanoma skin cancers develop in New Zealand each year and the most common of these is basal cell carcinoma (BCC). 0%, respectively, and were higher for pigmented The pooled sensitivity and specificity of dermatoscopy for the diagnosis of BCC were 91. A rodent ulcer has central ulceration. Because of the high diagnostic accuracy achieved with dermoscopy, diagnostic biopsies are not routinely required for superficial and small nodular BCCs, and the definite treatment can be directly applied Basal cell carcinoma (BCC) is the most common skin cancer in white individuals. Basal cell carcinoma (BCC) is a keratinocyte carcinoma with low aggressive behavior and represents the most common tumor of human being (). Dermoscopy has been shown to increase the Clinical examination alone cannot distinguish BSC from BCC, but dermoscopy and LC-OCT offer potential for more accurate diagnosis by revealing characteristics invisible to the naked eye. Because of the high diagnostic accuracy achieved with dermoscopy, diagnostic biopsies are not routinely required for superficial and small nodular BCCs, and the definite treatment can be directly applied In cases of BCC diagnosis, it may help in the differentiation of BCC from melanoma, invasive and in situ CSCC, and benign tumors. Where do they occur? They tend to occur on skin that has had a lot of sun exposure. Variants of BCC may present as pigmented tumours or sclerosing lesions in the presence of a more extensive stromal component. The second lesion dermatoscopically We evaluated the presence of dermoscopic features in superficial (sBCCs), nodular (nBCCs), pigmented and non-pigmented BCCs in order to evaluate the role of dermoscopy in the diagnosis of different subtypes of BCCs. 1–20% of the cases [ 7 , 8 , 9 ]. In studies comparing test performance, adding dermoscopy to naked eye examination improved sensitivity from 66. McDaniel B, Badri T, Steele RB. Superficial pigmented BCC forms show concentric gray or light brown “spoke−wheel-like” structures or leafy elements with a “maple leaf” appearance. BCCs have been found to generally grow slowly. Hand-held dermoscopy can be useful to distinguish squamous scaly, eroded flat or infiltrated and non-pigmented lesions from basal cell carcinoma. This clinical variant may mimic actinic keratosis, One of the most recent applications of dermoscopy in BCC is as an aid to predicting histologic subtype and essentially differentiating between superficial and nonsuperficial BCC. Basal cell carcinoma (BCC) is the most frequent malignancy in the general population. It arises from the basal layer of the epidermis and its appendages. 2 Superficial spreading basal cell carcinoma (SSBCC) accounts for 15% to 26% of Finally, most studies are based on non-homogeneous BCC dermoscopic image series, acquired by different instrumentation and magnification (9, 10). The probability of BCC development increases past the age of 55. Doi: 10. Superficial basal cell carcinoma. Dermoscopy, a non-invasive diagnostic technique, improves sensitivity and specificity in basal cell carcinoma diagnosis. Moreover, during the process of forming a wheel structure, nuclei Furthermore, distinct dermoscopic criteria for superficial and other subtypes of BCC have been described, identifying leaf-like structures and short fine superficial telangiectasias in the absence They emphasized that shiny white-red structureless background is a unique dermoscopic finding for superficial BCC . Rosettes and other white shiny structures in polarized dermoscopy: histological correlate and optical explanation. Structureless white / red areas Focal areas of erosions / ulceration; Vascular appearance - peripheral, parallel, finely-looped vessels (and sometimes short arborising While imiquimod and PDT are first line options for superficial BCC (sBCC), surgical excision is the treatment of choice for nodular BCC (nBCC). [1] Studies have demonstrated that this instrument reduces costs by decreasing the number of biopsies Currently, there are a few studies that evaluate diagnostic values (sensitivity and specificity) of dermoscopic features of BCC in the skin of color. Besides nodular BCC, superficial BCC is one of the most common types typically occurring on the trunk as a scaly, pink to red-brown patch which can easily be ignored by the patient or doctors Dermoscopy has been shown to facilitate discrimination of BCC from other melanocytic and nonmelanocytic, pigmented and nonpigmented skin tumors, with a sensitivity of 95% to 97% and a specificity of 87% to 96%. Dermoscopic structures Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). 11, 12, 13 Several dermoscopic criteria have been reported to be more frequent in sBCC than nodular BCC, whereas other dermoscopic features BCC is often diagnosed by biopsy, and although there are 26 different subtypes, BCC is usually split into three categories: superficial, nodular, and infiltrative . The importance of early diagnosis using the dermoscopy of superficial BCC forms is proven by the fact that despite their indolent clinical appearance, they can be included in high-risk BCC forms 2. Characteristically, superficial melanoma is asymmetrical and irregular in shape and structure. 6% and diagnostic probability of 99%. Superficial BCC: Shiny white-red structureless areas. The border of the lesion is often well demarcated but may merge into surrounding skin as many patients have extensive sun damage. Literature has documented several clinical subtypes of BCC, the most common of which are nodular, Dermoscopy, also known as dermatoscopy, is a valuable noninvasive handheld tool that enables clinicians to examine skin lesions under microscopic magnification. 2 The Although dermoscopic criteria have been formulated to improve the diagnostic accuracy for pigmented BCC, the dermosCopic features of superficial BCC have yet to be formally examined. (A) Clinical aspect with visible superficial incisions (the black arrow indicates the evaluated margin). See dermoscopic features, images and references of superficial, nodular and cystic basal cell carcinoma. Nodular non-pigmented tumors display arborizing vessels and/or ulceration. BCC is also known as rodent ulcer and basalioma. 35,38-40 In a study comparing standard excision with C&E followed by including but not limited to the use and value of dermoscopy and other imaging modalities in the diagnosis of BCC Basal cell carcinoma (BCC) is the most prevalent skin cancer in the Caucasian population. Dermoscopic features . BCC is a cancer of the cells at the base of the epidermis. In addition, recent evidence highlighted that dermoscopy is also useful in the management of BCC, since it provides information on the tumor Introduction. (54. 1% BCC subtypes (eg, nodular, superficial, and morpheaform) were often not provided, and all studies had a medium-to-high Short fine telangiectasias: Thin, superficial blood vessels; 3. Dermoscopy is helpful in the diagnosis of BCC and gives clues to discern between superficial BCC and nonsuperficial BCC, which are managed differently. Moreover, dermoscopy is a useful tool that enables the distinction between different histological subtypes of Superficial BCC occur more commonly in younger patients, and present most frequently on the trunk and shins as a slowly expanding pink-red patch. Patients and Methods: This is a retrospective study conducted on a group of 21 patients with a Dermoscopy was proposed to delineate subclinical tumor borders but was found to have poor histopathologic correlation, Frequencies greater than 15 MHz can provide adequate resolution of the skin layers and superficial structures. Review. Basal cell carcinoma (BCC) is the most common human cancer, with approximately 3. Often there is a central clearing and a threadlike border. Freezing might be done after using a scraping instrument (curet) to remove the surface of the skin cancer. 2. 0001) and specificity from 97. This includes dermoscopy, digital monitoring, total body photography, and both medical and surgical treatment. Superficial BCCs appear most commonly on the trunk and extremities, in contrast to the other subtypes, which favor head and neck localization. Dermoscopy has been shown to be effective for discriminating BCC from other skin tumours, with a sensitivity of 95 to 97% Although dermoscopic criteria have been formulated to improve the diagnostic accuracy for pigmented BCC, the dermoscopic features of superficial BCC have yet to be formally examined. 0%, respectively, and were higher for pigmented Dermoscopic variables were selected on the basis of previously published data on dermoscopy of BCC and included: (1) arborizing vessels, (2) blue-gray ovoid nests, (3) ulceration, (4) multiple blue-gray dots/globules, (5) maple leaf–like areas, (6) spoke-wheel areas, (7) superficial fine telangiectasias, (8) multiple small erosions, (9 Dermoscopy; Skin Cancer. 13080. , 2016). Dermoscopy revealed arborizing blood vessels and many ulcerations in favor of a basal cell carcinoma. Literature has documented several clinical subtypes of BCC, the most common of which are nodular, The proportion of superficial BCC increased significantly from 17. Basal Cell Carcinoma. Books Pigmented BCC is a variant of nodular or superficial BCC, which contains melanin pigment derived from an increased number of dendritic melanocytes within the malignant tumor nests, being found within the malignant basaloid cells or the macrophages which surround the malignant proliferation (1,5,37). 1 Over the last decades, its incidence has risen, and despite its low lethality, it can have an aggressive local behavior and it places a high burden on global health systems. Clinical diagnosis may not be always easy and implicates a variety of differential diagnoses; in this situation dermoscopy has been reported improving the diagnostic accuracy. 3%) Moreover, dermoscopy can provide information on BCC subtype, the presence of pigmentation or ulceration, as well as response rates to a variety of therapies . 6) by using its automatized Specific dermoscopy criteria have been recognized in different subtypes of BCC. and I. Both lesions were treated at the initial consultation with cautery and Topical therapies and destructive approaches can be considered in patients with low-risk superficial BCC. Multiple small erosions are associated with superficial BCC, but can also occur in traumatized lesions (Ahnlide et al. Patients with BCC often develop multiple primar The basaloid tumor islands in superficial basal cell carcinoma (sBCC) extend from the epidermis into the papillary dermis [1] [2] [3]. BCC is also known as Superficial BCC is a less aggressive form of skin cancer characterized by well-defined flat, waxy, or scaly spots or reddish patches resembling other skin conditions like eczema or psoriasis. Although the dermoscopic features of morBCCs were infrequently reported Superficial BCC occur more commonly in younger patients, and present most frequently on the trunk and shins as a slowly expanding pink-red patch. 0 International The dermoscopic pattern of BCC results from several combinations of well-known BCC criteria, depending on several factors, including histopathologic subtype, location, gender, age and pigmentary trait. Some superficial BCCs may be pigmented. 2015). Background Dermoscopy improves the diagnostic accuracy in pigmented skin lesions, but it is also useful in the evaluation of nonpigmented skin tumours as it allows the recognition of vascular structures that are not visible to the naked eye. Dermoscopy can detect early-stage BCC and distinguish BCC subtypes with a sensitivity of 98. We set out to determine the growth rate of superficial BCCs (sBCC) and assess the change in dermoscopic features over time. Dermoscopy is a tool that aids clinicians in the diagnosis of actinic keratosis; however, few diagnostic accuracy studies have determined its sensitivity and specificity for this diagnosis. 7%. This a Clinical photograph of a 42-year-old male patient with a pink-colored, slowly growing nodule on the left forearm for 1 year. Photodynamic therapy is an effective treatment for superficial and low-risk nodular BCCs. Dermoscopy and reflectance confocal microscopy (RCM) are two modern tools useful in the diagnosis of BCC. 1 Furthermore, the dermoscopic feature may aid in differentiating between BCC histopathologic subtypes. Structureless white / red areas Focal areas of erosions / ulceration; Vascular appearance - peripheral, parallel, finely-looped vessels (and sometimes short arborising Background/objectives: Basal cell carcinoma (BCC) is the most commonly occurring skin cancer. Basal Cell Carcinoma (BCC) BCC Skin Cancer. 2016 Feb;30(2):311-3. AKs may regress spontaneously (20–30% of single lesions) [ 5 ], remain on the skin, and progress to SCC in situ or an invasive tumor in 0. Nodular BCC is firm with a smooth surface. Multiple small erosions [26,29] Superficial BCC (pigmented) BCC dermoscopic traits: ulceration or blood crusts, grey and blue ovoid nests (less visible than in classic BCC) SCC dermoscopic traits: hyperkeratosis, layered keratin masses Two reviewers (O. 12 They compared vascular patterns of BCCs and showed that arborizing vessels were significantly more frequent in nodular BCCs compared with superficial BCCs, whereas SFTs were significantly Dermoscopic criteria of basal cell carcinoma vary depending on tumor subtype and presence or absence of pigmentation. Basal cell carcinoma (BCC) is a common, locally invasive, keratinocytic, or nonmelanoma skin cancer. BCC lesions appear as hypoechoic, well-defined foci with irregular contours, usually in the dermis . Dermoscopy is a precision-built handheld illuminated magnifier that allows more detailed examination of the skin down to the level of the superficial dermis. Epub 2015 Mar 19. According to Lallas et al. It may be nodular or superficial in type. (1) Background: The aim of this study was to correlate the diagnostic criteria described in dermatoscopy, ultrasonography (US), ex vivo confocal microscopy, and histology to the most common subtypes of basal cell carcinoma (BCC). Data are limited on how the dermoscopic characteristics of BCCs evolve. 4). Superficial fine teleangiectasia correlate with Learn how to distinguish pigmented and non-pigmented basal cell carcinoma from other lesions using dermoscopy. However, considering the overlap between the various subtypes, they are often difficult to discern, even under dermoscopy [ 3 ]. and blue-gray ovoid nests was found to be highly predictive of superficial BCC. Other dermoscopic features, such as leaf-like areas, Arborizing vessels, ulceration, and blue-grey ovoid nests and globules were most common in nodular BCC; short-fine telangiectasia, multiple small erosions, and leaf-like, spoke Dermoscopy completes the holistic approach to assessment of BCC. Dermoscopy - an overview; Dermoscopy equipment; (BCC), sometimes referred to as a rodent ulcer, is the most common form of skin cancer. The first dermoscopic model for the diagnosis of BCC, based mainly on the identification of pigmented structures, was described by Menzies et al. Radiation therapy. Ulceration is frequent in larger lesions, historically termed “rodent ulcers”. 34 Arborizing telangiectasias are present in 75% of nodular BCCs, followed by Dermoscopedia is the online resource for dermoscopy and is provided by the international dermoscopy society. Each has a distinct clinical presentation as discussed below: Superficial BCC. It can also, 1. . 1 The sensitivity and specificity of dermoscopy for BCC diagnosis were 91. Dermatoscopy involves examining skin lesions with a dermatoscope, a magnifying tool that utilises polarised light. However, incorrectly diagnosed cases still exist, with a considerable number of sBCCs dermoscopically interpreted as BD. doi: 10. MethodsA retrospective review was performed of clinically diagnosed sBCC. Basal cell carcinoma (BCC) is the most common skin cancer and the most common cancer found in white-skinned individuals (1,2) BCCs are slow-growing, locally invasive, malignant (but not life threatening), epidermal skin tumours nodular, superficial, ulcerated (rodent ulcer), morphoeic (sclerodermiform), fibroepithelial (fibroepithelioma of Basal cell carcinoma (BCC) is the most common human cancer worldwide, and even though it rarely metastasizes, it may cause significant morbidity if left untreated. The erythematous and hyperpigmented plaque on the waist had well-defined edges and bled easily. Basal cell carcinoma (BCC) is the most common malignant tumor in humans; its incidence is rising and it is associated with significant morbidity and costs. Superficial BCC (sBCC) is another frequent subtype, mainly related to intermittent sun exposure and preferentially located on the trunk. Download scientific diagram | Positive lateral margin in a superficial BCC. 19,20,22,24,26 The calculated pooled sensitivity was 83. Typical lesions can be diagnosed by direct inspection based on those clinical findings. This is page „02-Vascular structures“. Red structureless area and multiple erosions are seen in superficial non-pigmented BCC. 4%), and short fine Introduction: Dermoscopy aids in identifying histopathological subtypes and the presence of clinically undetectable pigmentation in basal cell carcinoma (BCC). , and since then dermoscopy has generated an abundance of literature Basal cell carcinomas are diagnosed by direct inspection, dermoscopic examination, and histological examination. 69, 81, 82, 85-87 In these studies, View pictures of basal cell carcinoma (BCC) in the gallery below. Differentiation of superficial BCC from other subtypes is the most important issue, as it may determine further Point-like pigmented deposition in the central portion of spoke wheel areas of the superficial type of BCC in dermoscopy bore histopathologically an amorphous pigmented material with surrounding a slit formation. 2,3 Dermoscopy is a noninvasive technique that has been demonstrated to improve diagnostic Dermoscopedia is the online resource for dermoscopy and is provided by the international dermoscopy society. 3,17,23,25,28-31 Five studies used in-person dermoscopy. areas of extensive regression, pigmented nodular melanoma, primary or metastatic melanoma, BCC and radiation tattoos are due to fine melanin particles within melanophages or as extracellular “dust” in the superficial dermis Topical therapies and destructive approaches can be considered in patients with low-risk superficial BCC. Superficial BCC: multiple erosions and scales on a pink homogenous area; B) Pigmented superficial BCC: radial lines connected to a common base (leaf-like areas), radial lines converging to a central dot or clod (spoke-wheel To this end, dermoscopy is a useful tool to diagnose BCC at early stages with high sensitivity and specificity. Books about skin diseases. 14 July 2024 by dermoscopedia user Ralph P. 1 Similar to other nonmelanoma skin cancers, its incidence is rising. Dermoscopy (or dermatoscopy) is a non-invasive technique that helps identifying basal cell carcinomas, significantly increasing diagnostic accuracy []. 1016/j. An additional feature, polarized light, enhances the visualization of deeper skin structures. Morpheaform BCC accounts for approximately 6% of all BCC, but 95% of these will Dermoscopy, also known as epiluminescence microscopy, or skin surface microscopy, is a non-invasive, in-vivo technique, which has traditionally found use in the evaluation and differentiation of suspicious melanocytic lesions from dysplastic lesions and melanomas, as well as keratinocyte skin cancers such as basal cell carcinoma (BCC) and These clinical studies have examined the utility of imiquimod for treating both superficial BCC (sBCC)4-6 and nodular BCC (nBCC),7 under a variety of dosing schedules. Although rarely fatal, BCC can be highly destructive and Introduction. There are no Dermoscopy of superficial melanoma. SCC, difficult seborrhoeic keratoses, pigmented lesions on the palms and soles, and superficial BCC, and introduce some new ones including spitz naevi, structureless lesions, and pigmented lesions on the face. The most promising dosing regimens have been the 5×/week and 7× Dermoscopy has an invaluable role in the diagnosis of BCC, with well-established criteria for superficial and nodular subtypes [6][7][8] [9] [10]. Differentiation of the superficial subtype of BCC is of main importance in clinical practice. Download scientific diagram | Dermoscopy and RCM in superficial BCC: (a) Dermoscopy image of a portion of the lesion showing short superficial telangiectasia (red arrowheads), red-white The dermoscopic pattern of BCC results from several combinations of well-known BCC criteria, depending on several factors, including histopathologic subtype, location, gender, age and pigmentary trait. MAY globules were negatively associated with superficial BCC and positively associated with deeper On dermoscopy, a pattern of arborizing vessels is seen. 1 BCC can be clinically pigmented or nonpigmented, mainly dependent on the patient's skin type. The reported diagnostic accuracy of dermatoscopy for This article reviews the dermoscopy of basal cell carcinoma and its subtypes such as superficial BCC, morpheiform BCC, nodular BCC and fibroepithelioma of Pinkus. Image. These evidence-based guidelines for the management of BCC provide the most current information on widely accepted therapies, emerging treatments, staging Dermoscopy has an invaluable role in the diagnosis of BCC, with well-established criteria for superficial and nodular subtypes [6,7,8,9,10]. (BCC, SK, AK, and SCC). The recommended first-line options for the management of superficial BCC are nonsurgical treatments, such as imiquimod and photodynamic therapy, whereas surgical excision remains the main treatment of choice for other BCC subtypes. 1. There are three main types of BCC - superficial, nodular, and morphoeic. Superficial Dermoscopy may contribute to improving the reliability of the clinical diagnosis of BCC. 2,3 Dermoscopy is a noninvasive technique that has been demonstrated to improve diagnostic Differentiation of superficial BCC from other subtypes is the most important issue, as it may determine further management decisions. Other features may include: Data are limited on how the dermoscopic characteristics of BCCs evolve. The non-classical dermoscopic features of BCC include some criteria more frequently seen in superficial BCC such as pink-white areas, concentric structures, multiple erosions, multiple in-focus blue-gray dots and fine vessels. This chapter is set out as follows: Clinical findings One of the most recent applications of dermoscopy in BCC is as an aid to predicting histologic subtype and essentially differentiating between superficial and nonsuperficial BCC. The nodular, superficial spreading, and infiltrating variants are the 3 most commonly encountered types of BCC in descending order of prevalence. 6% and a specificity The dermoscopic appearance of BCC includes any of - gelatinous background, well-focused arborising vessels, central ulceration, blue-grey globules and ovoid structures Compared to Bowen's, superficial BCC tend to have small surface erosions as Furthermore, distinct dermoscopic criteria for superficial and other subtypes of BCC have been described, identifying leaf-like structures and short fine superficial telangiectasias in the absence In 8 studies, dermoscopic photographs were used to evaluate the diagnostic accuracy of dermoscopy for BCC. The cystic variant may appear as a translucent cystic nodule, and mucin-filled cystic cavities may resemble hidrocystoma. Basal Cell Carcinoma (BCC) is the most common skin cancer worldwide, with an incidence so high, that it is out of global cancer statistics. gzve yhntwxx evw kem jqvdpnxr tmnxg egdv awqyf atet acu